Regenerative Medicine

Stem Cell Therapy for Knee Pain

Stem cell therapy for knee pain offers a powerful regenerative alternative for patients with knee osteoarthritis, meniscus tears, and cartilage damage who want to avoid or delay knee replacement surgery. By injecting concentrated stem cells directly into the knee joint, the aim is to support the cartilage, calm chronic inflammation and improve how the joint works.

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Conceptual illustration

Accepting new patientsNorth Georgia East TennesseeFind your clinic

Updated September 2026

Conditions Treated

Knee osteoarthritis (mild to severe), meniscus tears, articular cartilage defects, chronic knee pain after previous surgery, patients wanting to avoid or delay total knee replacement

Arthritis Joint Pain

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The treatment explained

How It Works

Autologous stem cells are harvested from your bone marrow or adipose tissue and concentrated. Under ultrasound guidance, the regenerative cell concentrate is injected directly into the knee joint, targeting areas of cartilage loss and inflammation. PRP (platelet-rich plasma) is often combined with stem cells to amplify the healing response.

Conceptual illustration: Knee joint with highlighted menisci and cartilage

Treatment day

What to Expect

90-120 minute procedure. Performed in our clinic under local anesthesia. You will walk out the same day. Crutches or a brace may be recommended for the first few days. Expect swelling and mild discomfort for 1-2 weeks as the healing cascade activates.

Afterward

Recovery

Limited weight-bearing for 3-5 days. Gradual return to walking and daily activities over 2-4 weeks. Return to full activity at 6-12 weeks. Physical therapy is strongly recommended to optimize outcomes.

Duration of Relief

How much a knee improves depends on the grade of arthritis, your weight-bearing demands and what the joint already looked like on imaging, so we talk through your own films at the consultation.

Regulatory status. FDA approvals apply to specific products and conditions. For example, Ryoncil is approved for steroid-refractory acute graft-versus-host disease in children aged 2 months and older.[1] That approval does not cover the orthopedic treatments described here. A treatment that concentrates your own bone marrow or adipose tissue is not FDA-approved for knee arthritis, and we will go through what that means for you, and what the alternatives are for your diagnosis.

Plan on crutches or a brace for the first few days afterwards. The 90-120 minute procedure is done in our clinic under local anesthesia and you walk out the same day, with swelling and mild discomfort expected for 1-2 weeks. Whether it is an appropriate option depends on your imaging and what you have already tried, so request an appointment to go through both. Request an appointment

Limitless Performance Medicine

Our regenerative medicine program is powered by Limitless Performance Medicine — advanced regenerative protocols delivered with interventional pain precision. Limitless is a separate practice founded and owned by Dr. Joshua Hare, IPC's Founder & Medical Director.

Learn More at Limitless →

References

Clinical sources for this page.

U.S. Food and Drug Administration. FDA Approves First Mesenchymal Stromal Cell Therapy to Treat Steroid-Refractory Acute Graft-Versus-Host Disease. Immediate release, December 18, 2024. Back to first citation ↑

Five clinics

Book a visit

Our fellowship-trained physicians are accepting new patients at five clinics: Dalton, Ringgold, Cleveland, Farragut and Oak Ridge.

Request a callback Call (706) 847-0826